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Topics covered include the gamut of neuroprotection and neurorepair;
the Table of Contents from the 10th ICNA is listed below:

I. Neurodegenrative Diseases

Mandel            Biomarkers for prediction and targeted prevention of Alzheimer’s and Parkinson’s

                          diseases: evaluation of drug clinical efficacy

 

Cicchetti         Neuroprotective approaches enhancing brain neurotrophic support and their implication

                          in the treatment of Parkinson’s disease.

 

Lin                    Autophagy is involved in the protection by serum deprivation preconditioning of

                          MPP+-induced neurotocicity.

 

Wood               Regulation of the HMG-coa Reductase Pathaway in Brain of Alzheimer’s patients.

                          Specific targeting of Isopreniods but not cholesterol.

 

Solomon         Automated brain volume measurement in clinical practice: Literature review and early experience.

 

II.  Nanotechniques

Behnke            The control of growth and differentiation of cells with physical interaction.

Silva                 Engineering methods for making sense of the function of neural circuits and networks from cell signaling.

Tosi                 Nanoparticles for brain delivery of drugs: IN VIVO experiments and mechanism of BBB crossing.

 

Koehne           Carbon nanofiber electrode and wireless instantaneous neurotransmitter concentration sensor system

                         for fast scan cyclic voltammetry detection of dopamine and adenosine.

 

Andrews         Nanotechnology for neuromodulation: Lessons from sensory neuroprostheses.

 

 

III. Nervous System Injury-Spinal Cord and Nanoparticles

 

Feng                 Neuroprotective effects of Brdykinin B2 receptor antagonist Hoe-140 in spinal cord injury are

                          mediated through nitric oxide-related mechanisms.

 

Huang               A combination of CNTF, GDNF And BDNF applied topically over the injured spinal cord improves

                          functional recovery and reduces hemeoxgenase-2(HO-2) expression, blood-spinal cord barrier permeability,

                          edema formation and cellular damage in the rat.

 

Winkler            Ibuprofen and Indomethacin attenuate changes in the spinal cord evoked potentials recorded from the

                         epidural space after spinal cord injury and induce marked neuroprotection. An experimental study using

                         morphological and pharmacological approaches in the rat.

 

Lafuente         Engineered nanoparticles from metals Ag, Cu an Al(50-60 Nm) induce oxidative stress, neuronal nitric

                        oxide synthase upregulation and cell injury in the brain. Neuroprotective effects of insulin like growth factor-1.

 

Sharma          Chronic exposure of silica dust (Sio2 nanoparticles) exacerbate stress symptoms, cognitive dysfunction

                        and brain pathology following hyperthermic brain injury.

 

 

 

IV. Neurotoxicity-Anesthetic Agents

 

Jevtovic-Todorocic        Anesthesia-induced impairment of developmental synaptogenesis: The role of mitochondrial regional distribution.

 

Paule                               Neonatal ketamine anesthesia and long-lasting cognitive deficits in rhesus macaques.

 

Pontén                             Propofal induces dose related upregulation of heat shock protein (Hsp 72 Kd) response

                                          I the developing mice brain.

 

Todorovic                        Free radical signaling underlies subunit-specific inhibition of Cav3.2 T-type calcium channels by nitrous oxide.

 

Slikker                            The influence of pediatric anesthetics on the  developing animal brain.

 

 

 

V. Neuroprotection Techniques/Agents

 

Kuffler                 Neuroprotection by hypothermia and alkalinization against excitotoxicity and oxidative stress.

 

Liu                       Environmental enrichment preserves cortical inputs to the parahippocampal areas and reduces

                            post stroke diaschisis.

 

Marini                 The neuroprotective effect of Alpha-Linolenic Acid, an omega-3 fatty acid, against Soman-induced neuropatholgy.

 

Braga                 The Glur5 Kainate /AMPA receptor antagonist LY293558 reduces Soman-induced seizures and neuropathology.       

 

 

 

VI. Genomics

 

Oxenkrug             Genetic polymorphism of IFNG (+874) gene and Pteridines/Kynurenines  inflammation cascade.

 

Wiklund                Mechanisms of neuroprotection by Methylene Blue: Effects on the genomic response to reperfusion

                              injury induced by cardiac arrest and cardiopulmonary resuscitation in porcine brain.

 

Oxenkrug             Interferon-Gamma (+874) T/A genotypes and risk Of IFN-Alpha-induced depression.

 

Mandel                 Predictive diagnosis, targeted prevention, personalized health: An outlook.

 

 

 

VII. Neuroprotection Techniques/Agents (2)

 

Patnaik             Pretreatment with 5-HT3 receptor antagonist ondansetron attenuates morphine withdrawal

                          induced neurotoxicity, blood-brain barrier dysfunciton, glial activation and heat shock protein.

 

Wakasugi         Investigation of a neuroprotective mechanism of human neuroglobin.

 

Virmani             Modulation of carnitine palmitoyltransferase enzyme system by carnitine in cultured rat cortical

                           neurons at different ages of development.

 

Collins              Neuroprotective signal transduction mechanisms triggered by preconditioning brain cultures with

                          moderate, non-neurotoxic ethanol concentrations.

 

Lazarovici       The neuroprotective role of human umbilical cord blood nerve growth factor in ischemia.

 

VIII. Heat Stress

Pant                 Astrocytes are sensitive indicators of hyperthermia induced brain pathology in normal and

                         in Cu nanoparticles treated rats. An experimental study using immunohistochemical and

                         pharmacological approaches.

 

Smith                Age-related changes in lectin binding in the rat brain following heat stress. Implications for brain

                          pathology and neuroprotection.

 

Yilmaz               Increased arteriovenous differences in circulating serotonin levels and decrease in lung monoamine

                          oxidase activity closely corresponds to the pathophysiology of hyperthermic brain injury in the rat. New

                          roles of serotonin receptor modulation in neuroprotection.

 

Muresanu         Naoparticles exacerbate upregulation of heat shock protein (HSP 72 Kd), hemeoxygenase (HO-2) and

                          Proto-oncogene C-Fos expression in the rat brain areas exhibiting cell damage following heat stress.

                          Neuroprotective effects of cerebrolysin.

 

Zimmermann-Meinzingen     Cerebrolysin modulates aquaporin-4 expression, reduces brain edema formation and brain

                                                pathology in rats following heat stroke.

 

IX. Additional Topics

Collins             Chronic alcohol abuse and brain damage accretion: neuroprotective approaches.

Nyberg           Strategies for the repair of brain damage induced by anabolic androgenic steroids.

Lee                   Effects of androgrpaholide And 14-Deoxy-11, 12-didehydroandrographolide on cultured

                          primary astrocytes and PC12 cells.